Proof of Concept Portfolio
Real-world validation of single-cell intelligence across target discovery, MoA/ perturbation analysis, and clinical applications
From Target Discovery to Clinical Validation
See how innovation teams and bioinformatics validators aligned on WittGen output across
clinical applications, target discovery, and drug development programs.
See How We Apply Our Technology
Explore real-world applications across clinical validation, target discovery, and drug development
Case Studies
Detailed validation across therapeutic modalities
Hidden Subtype Detection in Breast Cancer
Revealing Misdiagnosed Cancer Populations at Single-Cell Resolution
Discovered hidden cancer subtypes missed by traditional bulk diagnostics. Found ER+ cells in TNBC-diagnosed patients and TNBC cells in ER+-diagnosed patients, preventing inappropriate treatment selection.
The Hidden Enemy in HER2+ Breast Cancer
Identifying Pre-Existing Resistant Clones (TOP2A+/RAD21+) Invisible to Traditional Profiling
Identified pre-existing drug-resistant cancer cell populations (TOP2A+/RAD21+) in treatment-naïve HER2+ breast cancer patients that are invisible to traditional bulk sequencing methods. T-DXd resistance isn't just acquired—it's often waiting there before treatment begins.
Mechanism-Based Patient Stratification
Beyond Expression: Identifying Functionally Active Targets
Distinguished between high expression and high functional activity using Gene Regulatory Network analysis. Eliminates false positive targets by confirming which pathways are actually driving disease.
bsADC Target Identification
Bispecific ADC Target Discovery
Identified validated druggable gene pairs across cancer subtypes with minimal off-tumor toxicity.
CDK-inhibitor MoA Analysis
Pathway Understanding in Breast Cancer
Identified transcription factors regulating CDK-inhibitor expression through regulatory network analysis.
PROTAC E3 Ligase Optimization
Cell-Type Specific Ligase Selection
Optimized E3 ligase selection at cellular resolution for PROTAC development.
ICI Response Biomarkers
T-cell Trajectory Analysis
Mapped T-cell trajectories to identify immune checkpoint inhibitor response biomarkers.
TKI Resistance Mechanisms
Resistance Pathway Analysis
Decoded cellular heterogeneity in TKI response to identify resistance mechanisms.
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